| Title:
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Methodological Approach for Modeling of Multienzyme in-pot Processes |
| Type:
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Article in proceedingsArticle in proceedings |
| Participant(s):
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Technical University of Denmark
Email:
Technical University of Denmark
Email:
Technical University of Denmark
Email:
Technical University of Denmark
Email:
Technical University of Denmark
Email:
|
| Abstract:
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This paper presents a methodological approach for modeling multi-enzyme in-pot processes. The methodology is exemplified stepwise through the bi-enzymatic production of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). In this case study, sensitivity analysis is also used to evaluate the reliability of all parameters of the model suggested in literature [5], Results, from the sensitivity analysis, are used as criteria for a systematic simplification of the model structure. Consequently, model complexity was reduced without compromising the general predictive performance. A deviation of less than 5% from the original model was found. |
| Published:
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part of: 21st European Symposium on Computer Aided Process Engineering (ISBN: 978-0-444-53895-6), pages: 1346-1350, 2011, Elsevier Science, |
| DOI:
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| Presented at:
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21st European Symposium on Computer Aided Process Engineering, Chalkidiki |
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