Tubular membrane reactors for immobilization of enzymes (TRIME)


The objective of the project is preparation of surface functional tubular membrane reactors with full control over surface properties. Ultimately, these systems will be used for immobilization of enzymes and applied as biocatalytic membrane reactors.


A new class of enzymes, cytochrome P450 monooxygenases (P450), have emerged as highly attractive enzymes for special synthesis and production of active pharmaceutical ingredients. These enzymes have an unmatched selectivity and could potentially be used across a broad range of fields. However, their stability and productivity is currently too low for industrial exploitation. Therefore there is a need for development of new biocatalytic reactors that can accommodate such unstable classes of enzymes.

The project

The project will be focused on surface modification of hollow fiber membranes to establish a platform and methodology for modification of this class of membrane. Typically such modification processes requires inert conditions and one of the initial milestones will be to establish a methodology permitting fast and efficient modification of such membranes. The project will combine advanced polymerization techniques with membrane science and biocatalysis to develop new biocatalytic membrane reactors.

The project is funded by FTP.

The project will be running from 2018-2021.


Supervisor: Assoc. Prof. A.E. Daugaard
PhD student: Libor Zverina
Co-supervisors: Prof. J.M. Woodley and Assoc. Prof. M. Pinelo, DTU



Libor Zverina
DTU Kemiteknik


Anders Egede Daugaard
DTU Kemiteknik
23 65 21 52