IL-based ISPR Design

(Ionic Liquid (IL) based in-situ product improval (ISPR) Design)


1. IL screening method development
2. IL database and software tool development
3. IL-based hybrid separation schemes design
4. IL-based ISPR design


Base on the advantages of hybrid reaction-separation schemes and the benefits of ionic liquid as media for bioreaction, integration of IL into hybrid reaction-separation schemes for bioprocesses, namely IL-based ISPR, is a promising area which holds potentials of opening up a new field of bio-chemical industry. However, these IL solvents present other challenges, among them difficulties in controlling water activity and pH, higher viscosity and problems with product isolation. Therefore, finding optimal ILs for specific bio-reaction tasks confidently and rapidly is essential.

The Project

In this PhD project, we will focus on developing a timely and systematic method of IL-based ISPR design including IL identification and process synthesis. Because the usual trial and error approach can be time consuming and expensive due to numerous ILs that may be considered as potential solvents, techniques such as computer aided molecular design (CAMD) is ideally suited as tailor-made ILs can be generated by adjusting the cation, anion, and side chains on the cation. Consequently, both comprehensive IL database and efficient IL screening method are needed. Meanwhile, a software tool will be developed for IL containing system.


Prof. John M. Woodley (Principal supervisor)
Prof. Georgios M. Kontogeorgis

The project is funded by Technical University of Denmark (DTU) and Chinese Scholarship Council (CSC), and will be running from October 2017 to October 2018.


Yuqiu Chen
DTU Kemiteknik