CAPEC-PROCESS. Foto: Thorkild Christensen

Research areas

Our research work, often in collaboration with industrial partners, involves two main components:

Process systems engineering (PSE)

  • We develop computer-aided tools for a broad range of processes including food and pharma production, manufacturing of chemicals and wastewater treatment / resource recovery.
  • We work with mathematical modelling and simulation, optimization, process synthesis and design, etc.
  • In recent years, Life Cycle Analysis (LCA) has developed into an important tool supporting traditional techno-economic analysis of process alternatives.

Bio-based processes (biocatalysis, fermentation and downstream processing)

We perform experimental and theoretical work that spans from microscale over lab and pilot-scale to full-scale activities, including also the digitalization of the systems studied.

  • Within fermentation, we work with pure and mixed cultures, and we have also developed activities involving scaling up/scaling down, computational fluid dynamics, and development/test of novel on-line sensors.
  • In biocatalysis, multi-step biocatalysis and in-situ product removal (ISPR) are investigated, as well as oxygen supply methods for bio-oxidations. Enzymes investigated include alcohol oxidases, carbohydrate oxidases, cytochrome P450s, Baeyer-Villiger monooxygenases, dehydrogenases, peroxidases, laccases and transaminases.
  • Within downstream processing, we cover a broad range of unit operations (e.g. distillation, crystallization, extraction), for example, investigating methods to obtain improved control of such processes, and have detailed expertise on different applications of membrane processes, particularly classical liquid operations – from microfiltration to reverse osmosis – and use of membranes for enzyme immobilization.

Our research areas cover:

  • Process systems engineering (PSE)

  • Bio-based processes (biocatalysis, fermentation and downstream processing)


Krist V. Gernaey
DTU Chemical Engineering
+45 45 25 29 70