Developing a validated technology platform for the application of oxygen dependent enzymes in synthesis and transformation of alcohols


The main objective for this project is to develop tools for implementing bio-catalytic synthesis and oxidation of alcohols.


Chemical oxidation methods are hazardous and have high environmental impacts. The development of bio-catalytic oxidation reactions is therefore desired, and would have a big impact on the future uptake of industrial biotechnology in Europe. To date, many oxidative bio-catalytic reactions have been identified in academic laboratories, but few have reached industrial application for transformation of unnatural substrates. 

The project

In this project we work to develop tools for implementing bio-catalytic synthesis and oxidation of alcohols. Experimental work is conducted to investigate different aspects such as suitable reactor configurations, methods of oxygen supply and its influence on the biocatalysts. A range of different biocatalysts are investigated within the project, such as oxidases and P450s. In addition, analysis of economic and environmental aspects is conducted.

BIOOX is a collaboration project between academic partners: DTU, The University of Manchester (coordinating partner), and University of Stuttgart, and industrial partners: BASF SE, CLEA Technologies BV, Prozomix Ltd, C-TECH Innovation Ltd, BiCT srl, Bio-Prodict BV, and Firmenich SA.

This project received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement n° 613849.

For more information please visit the BIOOX project website.


John Woodley
DTU Kemiteknik
45 25 28 85